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The reports insights were generated through a methodology that included systematic literature reviews, qualitative stakeholder interviews and development of a budget-impact model to benchmark current and future cost implications for the U.S

BER is initiated by DNA glycosylases, such as NTH1 and 8-oxoguanine-DNA-glycosylase (Ogg1), which recognize and remove the specific inappropriate base to form basic (apurinic/apyrimidinic

48 Studies comparing different dosages also found a dose-dependent increase in reduction of homocysteine levels with increasing dose

Starting at a low dose (like 0.25 mg) and gradually increasing over 4-16 weeks significantly reduces the severity and duration of side effects